diff --git a/changelog.d/10648.doc b/changelog.d/10648.doc
new file mode 100644
index 0000000000..4bd8df5236
--- /dev/null
+++ b/changelog.d/10648.doc
@@ -0,0 +1 @@
+Update the documentation to note that the `/spaces` and `/hierarchy` endpoints can be routed to workers.
diff --git a/docs/upgrade.md b/docs/upgrade.md
index 453dbbabe7..f9b832cb3f 100644
--- a/docs/upgrade.md
+++ b/docs/upgrade.md
@@ -85,6 +85,15 @@ process, for example:
     dpkg -i matrix-synapse-py3_1.3.0+stretch1_amd64.deb
     ```
 
+# Upgrading to v1.43.0
+
+## The spaces summary APIs can now be handled by workers
+
+The [available worker applications documentation](https://matrix-org.github.io/synapse/latest/workers.html#available-worker-applications)
+has been updated to reflect that calls to the `/spaces`, `/hierarchy`, and
+`/summary` endpoints can now be routed to workers for both client API and
+federation requests.
+
 # Upgrading to v1.42.0
 
 ## Removal of old Room Admin API
@@ -112,7 +121,6 @@ process failed. See the default templates linked above for an example.
 Users will stop receiving message updates via email for addresses that were
 once, but not still, linked to their account.
 
-
 # Upgrading to v1.41.0
 
 ## Add support for routing outbound HTTP requests via a proxy for federation
diff --git a/docs/workers.md b/docs/workers.md
index 3121241894..f1673d67d0 100644
--- a/docs/workers.md
+++ b/docs/workers.md
@@ -209,6 +209,8 @@ expressions:
     ^/_matrix/federation/v1/user/devices/
     ^/_matrix/federation/v1/get_groups_publicised$
     ^/_matrix/key/v2/query
+    ^/_matrix/federation/unstable/org.matrix.msc2946/spaces/
+    ^/_matrix/federation/unstable/org.matrix.msc2946/hierarchy/
 
     # Inbound federation transaction request
     ^/_matrix/federation/v1/send/
@@ -220,6 +222,9 @@ expressions:
     ^/_matrix/client/(api/v1|r0|unstable)/rooms/.*/context/.*$
     ^/_matrix/client/(api/v1|r0|unstable)/rooms/.*/members$
     ^/_matrix/client/(api/v1|r0|unstable)/rooms/.*/state$
+    ^/_matrix/client/unstable/org.matrix.msc2946/rooms/.*/spaces$
+    ^/_matrix/client/unstable/org.matrix.msc2946/rooms/.*/hierarchy$
+    ^/_matrix/client/unstable/im.nheko.summary/rooms/.*/summary$
     ^/_matrix/client/(api/v1|r0|unstable)/account/3pid$
     ^/_matrix/client/(api/v1|r0|unstable)/devices$
     ^/_matrix/client/(api/v1|r0|unstable)/keys/query$
diff --git a/synapse/app/generic_worker.py b/synapse/app/generic_worker.py
index 2eb8d5a79c..7d2cd6a904 100644
--- a/synapse/app/generic_worker.py
+++ b/synapse/app/generic_worker.py
@@ -69,39 +69,34 @@ from synapse.rest.client import (
     account_data,
     events,
     groups,
+    initial_sync,
     login,
     presence,
+    profile,
+    push_rule,
     read_marker,
     receipts,
     room,
     room_keys,
+    sendtodevice,
     sync,
     tags,
     user_directory,
+    versions,
+    voip,
 )
 from synapse.rest.client._base import client_patterns
 from synapse.rest.client.account import ThreepidRestServlet
-from synapse.rest.client.account_data import AccountDataServlet, RoomAccountDataServlet
 from synapse.rest.client.devices import DevicesRestServlet
-from synapse.rest.client.initial_sync import InitialSyncRestServlet
 from synapse.rest.client.keys import (
     KeyChangesServlet,
     KeyQueryServlet,
     OneTimeKeyServlet,
 )
-from synapse.rest.client.profile import (
-    ProfileAvatarURLRestServlet,
-    ProfileDisplaynameRestServlet,
-    ProfileRestServlet,
-)
-from synapse.rest.client.push_rule import PushRuleRestServlet
 from synapse.rest.client.register import (
     RegisterRestServlet,
     RegistrationTokenValidityRestServlet,
 )
-from synapse.rest.client.sendtodevice import SendToDeviceRestServlet
-from synapse.rest.client.versions import VersionsRestServlet
-from synapse.rest.client.voip import VoipRestServlet
 from synapse.rest.health import HealthResource
 from synapse.rest.key.v2 import KeyApiV2Resource
 from synapse.rest.synapse.client import build_synapse_client_resource_tree
@@ -288,32 +283,31 @@ class GenericWorkerServer(HomeServer):
                     login.register_servlets(self, resource)
                     ThreepidRestServlet(self).register(resource)
                     DevicesRestServlet(self).register(resource)
-                    KeyQueryServlet(self).register(resource)
-                    OneTimeKeyServlet(self).register(resource)
-                    KeyChangesServlet(self).register(resource)
-                    VoipRestServlet(self).register(resource)
-                    PushRuleRestServlet(self).register(resource)
-                    VersionsRestServlet(self).register(resource)
 
-                    ProfileAvatarURLRestServlet(self).register(resource)
-                    ProfileDisplaynameRestServlet(self).register(resource)
-                    ProfileRestServlet(self).register(resource)
+                    # Read-only
                     KeyUploadServlet(self).register(resource)
-                    AccountDataServlet(self).register(resource)
-                    RoomAccountDataServlet(self).register(resource)
+                    KeyQueryServlet(self).register(resource)
+                    KeyChangesServlet(self).register(resource)
+                    OneTimeKeyServlet(self).register(resource)
+
+                    voip.register_servlets(self, resource)
+                    push_rule.register_servlets(self, resource)
+                    versions.register_servlets(self, resource)
+
+                    profile.register_servlets(self, resource)
 
                     sync.register_servlets(self, resource)
                     events.register_servlets(self, resource)
-                    room.register_servlets(self, resource, True)
+                    room.register_servlets(self, resource, is_worker=True)
                     room.register_deprecated_servlets(self, resource)
-                    InitialSyncRestServlet(self).register(resource)
+                    initial_sync.register_servlets(self, resource)
                     room_keys.register_servlets(self, resource)
                     tags.register_servlets(self, resource)
                     account_data.register_servlets(self, resource)
                     receipts.register_servlets(self, resource)
                     read_marker.register_servlets(self, resource)
 
-                    SendToDeviceRestServlet(self).register(resource)
+                    sendtodevice.register_servlets(self, resource)
 
                     user_directory.register_servlets(self, resource)