diff --git a/src/stores/RoomViewStore.tsx b/src/stores/RoomViewStore.tsx
index 8ad0637672..e9f61afe8c 100644
--- a/src/stores/RoomViewStore.tsx
+++ b/src/stores/RoomViewStore.tsx
@@ -335,10 +335,11 @@ export class RoomViewStore extends EventEmitter {
                 this.reset();
                 break;
             case "reply_to_event":
-                // If currently viewed room does not match the room in which we wish to reply then change rooms
-                // this can happen when performing a search across all rooms. Persist the data from this event for
-                // both room and search timeline rendering types, search will get auto-closed by RoomView at this time.
-                if ([TimelineRenderingType.Room, TimelineRenderingType.Search].includes(payload.context)) {
+                // Thread timeline view handles its own reply-to-state
+                if (TimelineRenderingType.Thread !== payload.context) {
+                    // If currently viewed room does not match the room in which we wish to reply then change rooms this
+                    // can happen when performing a search across all rooms. Persist the data from this event for both
+                    // room and search timeline rendering types, search will get auto-closed by RoomView at this time.
                     if (payload.event && payload.event.getRoomId() !== this.state.roomId) {
                         this.dis.dispatch<ViewRoomPayload>({
                             action: Action.ViewRoom,
diff --git a/test/stores/RoomViewStore-test.ts b/test/stores/RoomViewStore-test.ts
index 30a8cff02c..7c2b1ec81b 100644
--- a/test/stores/RoomViewStore-test.ts
+++ b/test/stores/RoomViewStore-test.ts
@@ -15,6 +15,7 @@ limitations under the License.
 */
 
 import { Room } from "matrix-js-sdk/src/matrix";
+import { sleep } from "matrix-js-sdk/src/utils";
 
 import { RoomViewStore } from "../../src/stores/RoomViewStore";
 import { Action } from "../../src/dispatcher/actions";
@@ -245,6 +246,28 @@ describe("RoomViewStore", function () {
         expect(roomViewStore.getRoomId()).toEqual(roomId2);
     });
 
+    it("should ignore reply_to_event for Thread panels", async () => {
+        expect(roomViewStore.getQuotingEvent()).toBeFalsy();
+        const replyToEvent = {
+            getRoomId: () => roomId2,
+        };
+        dis.dispatch({ action: "reply_to_event", event: replyToEvent, context: TimelineRenderingType.Thread });
+        await sleep(100);
+        expect(roomViewStore.getQuotingEvent()).toBeFalsy();
+    });
+
+    it.each([TimelineRenderingType.Room, TimelineRenderingType.File, TimelineRenderingType.Notification])(
+        "Should respect reply_to_event for %s rendering context",
+        async (context) => {
+            const replyToEvent = {
+                getRoomId: () => roomId,
+            };
+            dis.dispatch({ action: "reply_to_event", event: replyToEvent, context });
+            await untilDispatch(Action.ViewRoom, dis);
+            expect(roomViewStore.getQuotingEvent()).toEqual(replyToEvent);
+        },
+    );
+
     it("removes the roomId on ViewHomePage", async () => {
         dis.dispatch({ action: Action.ViewRoom, room_id: roomId });
         await untilDispatch(Action.ActiveRoomChanged, dis);