diff --git a/.github/labels.yml b/.github/labels.yml
index 80c5408c1e..c8a34c4771 100644
--- a/.github/labels.yml
+++ b/.github/labels.yml
@@ -210,6 +210,9 @@
 - name: "X-Upcoming-Release-Blocker"
   description: "This does not affect the current release cycle but will affect the next one"
   color: "e99695"
+- name: "X-Run-All-Tests"
+  description: "When applied to PRs, it'll run the full gamut of end-to-end tests on the PR"
+  color: "ff7979"
 - name: "Z-Actions"
   color: "ededed"
 - name: "Z-Cache-Confusion"
diff --git a/.github/workflows/end-to-end-tests.yaml b/.github/workflows/end-to-end-tests.yaml
index 6afabdb1fe..4232993fa0 100644
--- a/.github/workflows/end-to-end-tests.yaml
+++ b/.github/workflows/end-to-end-tests.yaml
@@ -114,13 +114,13 @@ jobs:
                     - Chrome
                     - Firefox
                     - WebKit
-                isCron:
-                    - ${{ github.event_name == 'schedule' }}
-                # Skip the Firefox & Safari runs unless this was a cron trigger
+                runAllTests:
+                    - ${{ github.event_name == 'schedule' || contains(github.event.pull_request.labels.*.name, 'X-Run-All-Tests') }}
+                # Skip the Firefox & Safari runs unless this was a cron trigger or PR has X-Run-All-Tests label
                 exclude:
-                    - isCron: false
+                    - runAllTests: false
                       project: Firefox
-                    - isCron: false
+                    - runAllTests: false
                       project: WebKit
         steps:
             - uses: actions/checkout@v4
@@ -170,7 +170,7 @@ jobs:
                   yarn playwright test \
                       --shard "${{ matrix.runner }}/${{ needs.build.outputs.num-runners }}" \
                       --project="${{ matrix.project }}" \
-                      ${{ github.event_name == 'pull_request' && '--grep-invert @mergequeue' || '' }}
+                      ${{ (github.event_name == 'pull_request' && matrix.runAllTests == false ) && '--grep-invert @mergequeue' || '' }}
 
             - name: Upload blob report to GitHub Actions Artifacts
               if: always()
diff --git a/docs/playwright.md b/docs/playwright.md
index fe44a06ff1..cd19c41b6c 100644
--- a/docs/playwright.md
+++ b/docs/playwright.md
@@ -227,6 +227,8 @@ has to be disabled in Playwright on Firefox & Webkit to retain routing functiona
 Anything testing VoIP/microphone will need to have `@no-webkit` as fake microphone functionality is not available
 there at this time.
 
+If you wish to run all tests in a PR, you can give it the label `X-Run-All-Tests`.
+
 ## Supporter container runtimes
 
 We use testcontainers to spin up various instances of Synapse, Matrix Authentication Service, and more.