diff --git a/src/components/structures/RoomView.tsx b/src/components/structures/RoomView.tsx
index 2c118149a0..2d264b00e9 100644
--- a/src/components/structures/RoomView.tsx
+++ b/src/components/structures/RoomView.tsx
@@ -916,6 +916,7 @@ export default class RoomView extends React.Component<IProps, IState> {
     // called when state.room is first initialised (either at initial load,
     // after a successful peek, or after we join the room).
     private onRoomLoaded = (room: Room) => {
+        if (this.unmounted) return;
         // Attach a widget store listener only when we get a room
         WidgetLayoutStore.instance.on(WidgetLayoutStore.emissionForRoom(room), this.onWidgetLayoutChange);
         this.onWidgetLayoutChange(); // provoke an update
@@ -930,9 +931,9 @@ export default class RoomView extends React.Component<IProps, IState> {
     };
 
     private async calculateRecommendedVersion(room: Room) {
-        this.setState({
-            upgradeRecommendation: await room.getRecommendedVersion(),
-        });
+        const upgradeRecommendation = await room.getRecommendedVersion();
+        if (this.unmounted) return;
+        this.setState({ upgradeRecommendation });
     }
 
     private async loadMembersIfJoined(room: Room) {
@@ -1022,23 +1023,19 @@ export default class RoomView extends React.Component<IProps, IState> {
     };
 
     private async updateE2EStatus(room: Room) {
-        if (!this.context.isRoomEncrypted(room.roomId)) {
-            return;
-        }
-        if (!this.context.isCryptoEnabled()) {
-            // If crypto is not currently enabled, we aren't tracking devices at all,
-            // so we don't know what the answer is. Let's error on the safe side and show
-            // a warning for this case.
-            this.setState({
-                e2eStatus: E2EStatus.Warning,
-            });
-            return;
+        if (!this.context.isRoomEncrypted(room.roomId)) return;
+
+        // If crypto is not currently enabled, we aren't tracking devices at all,
+        // so we don't know what the answer is. Let's error on the safe side and show
+        // a warning for this case.
+        let e2eStatus = E2EStatus.Warning;
+        if (this.context.isCryptoEnabled()) {
+            /* At this point, the user has encryption on and cross-signing on */
+            e2eStatus = await shieldStatusForRoom(this.context, room);
         }
 
-        /* At this point, the user has encryption on and cross-signing on */
-        this.setState({
-            e2eStatus: await shieldStatusForRoom(this.context, room),
-        });
+        if (this.unmounted) return;
+        this.setState({ e2eStatus });
     }
 
     private onAccountData = (event: MatrixEvent) => {
diff --git a/src/components/structures/TimelinePanel.tsx b/src/components/structures/TimelinePanel.tsx
index 85a048e9b8..c21aac790b 100644
--- a/src/components/structures/TimelinePanel.tsx
+++ b/src/components/structures/TimelinePanel.tsx
@@ -1051,6 +1051,8 @@ class TimelinePanel extends React.Component<IProps, IState> {
             { windowLimit: this.props.timelineCap });
 
         const onLoaded = () => {
+            if (this.unmounted) return;
+
             // clear the timeline min-height when
             // (re)loading the timeline
             if (this.messagePanel.current) {
@@ -1092,6 +1094,8 @@ class TimelinePanel extends React.Component<IProps, IState> {
         };
 
         const onError = (error) => {
+            if (this.unmounted) return;
+
             this.setState({ timelineLoading: false });
             console.error(
                 `Error loading timeline panel at ${eventId}: ${error}`,
diff --git a/src/components/views/messages/SenderProfile.tsx b/src/components/views/messages/SenderProfile.tsx
index 5198effb32..d62c10427d 100644
--- a/src/components/views/messages/SenderProfile.tsx
+++ b/src/components/views/messages/SenderProfile.tsx
@@ -38,7 +38,7 @@ interface IState {
 @replaceableComponent("views.messages.SenderProfile")
 export default class SenderProfile extends React.Component<IProps, IState> {
     static contextType = MatrixClientContext;
-    private unmounted: boolean;
+    private unmounted = false;
 
     constructor(props: IProps) {
         super(props);
@@ -51,7 +51,6 @@ export default class SenderProfile extends React.Component<IProps, IState> {
     }
 
     componentDidMount() {
-        this.unmounted = false;
         this.updateRelatedGroups();
 
         if (this.state.userGroups.length === 0) {
@@ -67,30 +66,24 @@ export default class SenderProfile extends React.Component<IProps, IState> {
     }
 
     private async getPublicisedGroups() {
-        if (!this.unmounted) {
-            const userGroups = await FlairStore.getPublicisedGroupsCached(
-                this.context, this.props.mxEvent.getSender(),
-            );
-            this.setState({ userGroups });
-        }
+        const userGroups = await FlairStore.getPublicisedGroupsCached(this.context, this.props.mxEvent.getSender());
+        if (this.unmounted) return;
+        this.setState({ userGroups });
     }
 
     private onRoomStateEvents = (event: MatrixEvent) => {
-        if (event.getType() === 'm.room.related_groups' &&
-            event.getRoomId() === this.props.mxEvent.getRoomId()
-        ) {
+        if (event.getType() === 'm.room.related_groups' && event.getRoomId() === this.props.mxEvent.getRoomId()) {
             this.updateRelatedGroups();
         }
     };
 
     private updateRelatedGroups() {
-        if (this.unmounted) return;
         const room = this.context.getRoom(this.props.mxEvent.getRoomId());
         if (!room) return;
 
         const relatedGroupsEvent = room.currentState.getStateEvents('m.room.related_groups', '');
         this.setState({
-            relatedGroups: relatedGroupsEvent ? relatedGroupsEvent.getContent().groups || [] : [],
+            relatedGroups: relatedGroupsEvent?.getContent().groups || [],
         });
     }
 
diff --git a/src/components/views/settings/tabs/user/AppearanceUserSettingsTab.tsx b/src/components/views/settings/tabs/user/AppearanceUserSettingsTab.tsx
index 17aa9e5561..a94821e94a 100644
--- a/src/components/views/settings/tabs/user/AppearanceUserSettingsTab.tsx
+++ b/src/components/views/settings/tabs/user/AppearanceUserSettingsTab.tsx
@@ -76,6 +76,7 @@ export default class AppearanceUserSettingsTab extends React.Component<IProps, I
     private readonly MESSAGE_PREVIEW_TEXT = _t("Hey you. You're the best!");
 
     private themeTimer: number;
+    private unmounted = false;
 
     constructor(props: IProps) {
         super(props);
@@ -101,6 +102,7 @@ export default class AppearanceUserSettingsTab extends React.Component<IProps, I
         const client = MatrixClientPeg.get();
         const userId = client.getUserId();
         const profileInfo = await client.getProfileInfo(userId);
+        if (this.unmounted) return;
 
         this.setState({
             userId,
@@ -109,6 +111,10 @@ export default class AppearanceUserSettingsTab extends React.Component<IProps, I
         });
     }
 
+    componentWillUnmount() {
+        this.unmounted = true;
+    }
+
     private calculateThemeState(): IThemeState {
         // We have to mirror the logic from ThemeWatcher.getEffectiveTheme so we
         // show the right values for things.